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. 2019 Dec 19;105(5):1427–1434. doi: 10.1210/clinem/dgz277

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© Endocrine Society 2019.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Dose effect of hydrocortisone replacement on circulating GDF15. Serum GDF15 was measured in n = 20 healthy male volunteers with metyrapone inhibited endogenous cortisol synthesis who received low, medium, and high dose hydrocortisone replacement on three separate occasions. Exposure to increasing doses of hydrocortisone was associated with significantly lower GDF15 levels. Data expressed as mean ± standard deviation and compared using a one-way analysis of variance and post-hoc Tukey test, **P < .01, ***P < .001, ****P < .0001.