Figure 11.

Suppression of the growth of human ectopic lesions in SCID mice by DIM-C-pPhOH-3-Cl-5-OCH₃ (C-DIM). The human ectopic lesions were generated by injection of HECs expressing luciferase into SCID mice (A). At the third week after endometriosis induction, mice were randomly divided 2 groups. Mice in one group were treated with 25 mg/kg of C-DIM (once a day), and mice in the other group were treated with the vehicle (once a day) for 30 days. The luciferase activities of human ectopic lesions were determined at 4, 7, 16, 23, and 30 days after drug treatment (B). The luciferase activity of ectopic lesions treated with the vehicle and C-DIM were quantified. Based on these, the relative fold of luciferase activity compared to 0-day drug treatment was calculated (C). Abbreviation: DTD, drug treatment days.