Table 2. Single-Dose Pharmacokinetics of Six Vancomycin Products after Subcutaneous Administration of 100 mg/kg in Neutropenic Mice.
| Product | T1/2 (h) | Cmax (mg/L) | GMR (90% CI) | p value | AUC (mg*h/L) | GMR (90% CI) | p value |
|---|---|---|---|---|---|---|---|
| Vancocin CP | 0.83 | 86.92 | Reference | Reference | 135.93 | Reference | Reference |
| Generic A | 0.56 | 68.66 | 75.14 (65.84–85.76) | 0.001 | 100.73 | 78.88 (69.75–89.22) | 0.002 |
| Generic B | 0.59 | 71.83 | 75.16 (65.86–85.78) | 0.001 | 102.30 | 82.33 (72.80–93.12) | 0.011 |
| Generic C | 0.71 | 79.05 | 81.65 (71.54–93.18) | 0.013 | 114.4 | 87.97 (77.78–99.50) | 0.087 |
| Generic D | 0.70 | 77.95 | 84.77 (74.28–96.74) | 0.041 | 114.93 | 89.57 (79.20–101.31) | 0.140 |
| Generic E | 0.61 | 74.71 | 76.92 (67.40–87.79) | 0.001 | 104.66 | 86.32 (76.32–97.63) | 0.050 |
T1/2, half-life; Cmax, maximum serum concentration; AUC, area under the curve; GMR, geometric mean ratio of test/reference; CI, confidence interval.