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. 2019 Sep 9;19(2):427–444. doi: 10.1007/s10237-019-01219-0

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 4 — Histogram and CDF plot of outcomes at time of Monte Carlo simulations with 5000 samples. a There is no drug intervention. The x-axis shows the final fraction of cancer cells in total cells $f_{c}$ and the y-axis is its corresponding frequency of occurrence. b Cumulative probability $f < f_{c}$ based on the histogram in (a), where f is the dynamic fraction of cancer cells at time