Fig. 6.

Variation of ${\lambda }_2$, which is the tangential component of desmoplastic ECM orientation, in ten subdomains (see Fig. 2b) during time interval $(t_0,t_1)$. Since the injection site of PEGPH20 is chosen at the middle of subdomain 5 and 6, but outside of the desmoplastic ECM, the orientation ${\lambda }_2$ of subdomain 5 and 6 decreases faster as a result of sensing a higher PEGPH20 concentration