Table 1.

Input values

Parameters	Notation	Value and units	Source
Radius of cells	R	8 μm	De Paiva et al. (2006)
Radius of T-lymphocytes	$R_t$	5 μm	Estimated
Cell contraction force	F	30 kg μm/h2	Estimated
Substrate elasticity	$E_s$	5 kg/μm h2	Estimated
Cell elasticity	$E_c$	0.5 kg/μm h2	Estimated
Elasticity of T-lymphocytes	$E_t$	250 kg/μm h2	Estimated
Cell mobility coefficient	$\beta$	60 h-1	Estimated
Friction coefficient	$\mathrm{\mu }$	0.2	Vermolen and Gefen (2012)
Cytokine diffusivity	$D_{\mathrm{c}}$	5E3 μm2/h	Bookholt et al. (2016)
PEGPH20 diffusivity	$D_{\mathrm{en}}$	1E1 μm2/h	Young et al. (1980)
Drug diffusivity	$D_{\mathrm{drug}}$	1E4 μm2/h	Jeon et al. (2002)
Secretion rate	$\gamma$	5E6 mol/h μm3	Savinell et al. (1989)
Injection rate	${\gamma }_0$	5E6 mol/h μm3	Estimated
Time step	$\mathrm{d}t$	0.01 $\mathrm{h}$	Estimated
Inner radius of T-islet	$R_1$	120 $\mathrm{\mu }\mathrm{m}$	Estimated
Outer radius of t-islet	$R_2$	200 $\mathrm{\mu }\mathrm{m}$	Estimated