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. 2020 Mar 30;11:1600. doi: 10.1038/s41467-020-15383-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a The results of the combined meta-analysis across all cohorts; the dotted horizontal line indicates a genome-wide significance threshold (α = 5 × 10⁻⁸); the y-axis is truncated twice to accommodate large peaks over PLA2R1 and HLA loci; genome-wide-significant loci highlighted in red; b Regional plot for the PLA2R1 locus; the upper panel shows unconditioned meta-results, the lower panel depicts meta-results after conditioning for the top SNP (rs17831251). c Regional plot for the NFKB1 locus; the upper panel corresponds to unconditioned results; the lower panel shows meta-results after controlling for rs230540. d Regional plot for the IRF4 locus; the upper panel corresponds to unconditioned results; the lower panel shows meta-results after controlling for rs9405192. The x-axis denotes genomic location (hg19 coordinates), left y-axis represents –log P values for association statistics, right y-axis represents average recombination rates based on HapMap-III reference populations combined (blue line). In the conditional analyses, we conditioned on the top SNP in each individual cohort, then meta-analyzed conditioned summary statistics as described in the Methods.