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. 2020 Mar 30;11:1606. doi: 10.1038/s41467-020-15459-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a The molecular association of tetraspanin and its partner proteins is mediated through both the TM and LEL regions, but its dependency is different among the partner proteins. Lipid binding to the central cavity could modulate the molecular association by affecting the LEL conformation. b The highly asymmetric shape of the tetraspanins suggests their localization at high curvature regions and/or clustering-induced curvature generation. Partner proteins should also be recruited and sorted to the respective regions, such as the microvilli tips and microsomes (exosomes).