Table 3.
Factors affecting CR by logistic regression analysis.
| Parameters | Logistic regression model | |||
|---|---|---|---|---|
| P value | OR | 95% CI | ||
| Lower | Higher | |||
| Univariate logistic regression | ||||
| Age (≥18 vs. <18 years) | 0.999 | – | 0.000 | – |
| Gender (male vs. female) | 0.711 | 0.625 | 0.052 | 7.530 |
| Number of previous chemotherapies (≥4 vs. <4) | 0.418 | 2.800 | 0.232 | 33.779 |
| Refractory disease (yes vs. no) | 0.418 | 0.357 | 0.030 | 4.309 |
| Relapsed disease (yes vs. no) | 0.999 | 0.000 | 0.000 | – |
| Bone marrow blasts (≥5% vs. <5%) | 0.999 | – | 0.000 | – |
| Extramedullary disease (yes vs. no) | 0.711 | 0.625 | 0.052 | 7.530 |
| CNSL (yes vs. no) | 0.920 | 0.880 | 0.072 | 10.753 |
| BCR/ABL1 (positive vs. negative) | 0.920 | 0.880 | 0.072 | 10.753 |
| SH2B3 mutation (positive vs. negative) | 0.321 | 0.283 | 0.023 | 3.425 |
| PAX5 mutation (positive vs. negative) | 0.236 | 0.220 | 0.018 | 2.688 |
| WBC ( ≥ 30 × 109/L vs. <30 × 109/L) | 0.998 | 0.000 | 0.000 | – |
| Lymphodepletion regimens (Flu + Cy vs. non-Flu + Cy) | 0.920 | 0.880 | 0.072 | 10.753 |
| CAR-T cells (anti-CD19 + CD22 vs. anti-CD19) | 0.277 | 0.250 | 0.021 | 3.041 |
| Multivariate logistic regression | ||||
| No independent factor | – | – | – | – |
Factors affecting CR were determined by univariate and multivariate logistic regression analysis with Forward Stepwise (Conditional) method. P value <0.05 was considered significant.
CR complete remission, CNSL central nervous system leukemia, WBC white blood cell, OR odds ratio, CI confidence interval, Flu fludarabine, Cy cyclophosphamide, CAR-T chimeric antigen receptor T cells.