Table 5.

Factors affecting OS by Cox’s regression analysis.

Items	Cox’s regression model
	P value	HR	95% CI
			Lower	Higher
Univariate Cox’s regression
Age (≥18 vs. <18 years)	1.000	1.000	0.374	2.673
Gender (male vs. female)	0.850	0.914	0.359	2.324
Number of previous chemotherapies (≥4 vs. <4)	0.996	0.997	0.393	2.531
Refractory disease (yes vs. no)	0.028	2.914	1.122	7.571
Relapsed disease (yes vs. no)	0.199	0.365	0.079	1.697
Bone marrow blasts (≥5% vs. <5%)	0.065	2.557	0.945	6.921
Extramedullary disease (yes vs. no)	0.529	0.743	0.295	1.874
CNSL (yes vs. no)	0.084	0.333	0.096	1.158
BCR/ABL1 (positive vs. negative)	0.249	0.539	0.188	1.541
SH2B3 mutation (positive vs. negative)	0.198	0.480	0.157	1.468
PAX5 mutation (positive vs. negative)	0.167	0.417	0.120	1.444
WBC (≥30 × 109/L vs. <30 × 109/L)	0.695	1.205	0.474	3.066
Lymphodepletion regimens (Flu + Cy vs. non-Flu + Cy)	0.049	2.574	1.005	6.598
CAR-T cells (anti-CD19 + CD22 vs. anti-CD19)	0.263	1.925	0.611	6.059
CR with MRD negative (yes vs. no)	0.080	0.411	0.152	1.111
Bridging to HSCT (yes vs. no)	0.014	0.279	0.101	0.769
Multivariate Cox’s regression
Bridging to HSCT (yes vs. no)	0.014	0.279	0.101	0.769

Factors affecting OS were determined by univariate and multivariate Cox’s proportional hazards regression model with Forward Stepwise (Conditional) method. P value <0.05 was considered significant.

OS overall survival, CR complete remission, MRD minimal residual disease, CNSL central nervous system leukemia, WBC white blood cell, Flu fludarabine, Cy cyclophosphamide, CAR-T chimeric antigen receptor T cells, HSCT hematopoietic stem-cell transplantation, HR hazard ratio, CI confidence interval.