Table 3.

Comparative analysis of secondary metabolites clusters of Bacillus velezensis ZF2 identified in genome with plant-associated strains and reference genomes

Bacillus velezensis ZF2						Presence ( +) or absence ( − ) of secondary metabolites clusters in Bacillus strains
Metabolites	Synthetase	Core gene cluster	Size	Position	Bioactive spectrum	FZB42T	LS69	DSM7T	168 T
Surfactin	NRPS	srfAABCD, bsdAB	66,231 bp	321,977–388,208	Virus, mycoplasma and fungi	+	+	+	+
Butirosin	OtherKS	yhdFR, pksAF, citR, rpoE, cueR	42,049 bp	923,781–965.830	Bacteria, Cyanobacteria	+	+	+	−
Macrolactin	TransATPKS	mlnABCDEFGH, kinC, speA	87,409 bp	1,385,009–1,472,418	Bacteria	+	+	−	−
Bacillaene	TransATPKS-NRPS	pksCDEJLMNRS, miaB, aprX	102,336 bp	1,698,684–1,801,020	Bacteria	+	+	+	+
Fengycin	TransATPKS-NRPS	kdgR, yvrGH, ituABCD, yxiF, bioBFI, fenABCDE,yngI	138,886 bp	1,865,753–2,004,639	Filamentous fungi	+	+	+	+
Difficidin	TransATPKS	dfnABCDEFGHIJK, yqkD, lysR, yqiL	100,585 bp	2,270,261–2,370,846	Bacteria	+	+	−	−
Bacillibactin	Bacteriocin-NRPS	dhbABEF, besA, ublA, yuxL, lipA	68,245 bp	3,000,664–3,068,909	Microbial competitors	+	+	+	+
Teichuronic acid	Saccharide	degSU, tagO, tuaABCEGH, mnaA, ggaA, opuBCD	56,166 bp	3,389,585–3,445,751	Bacteria	+	+	+	+
Bacilysin	NRPS	bacABCDE, cysL, ycbL, rfbBCD, spsABCG, ywdF, vpr, nfrA	73,132 bp	3,589,054–3,662,186	Bacteria and Candida albicans	+	+	+	+
Citruline	Fatty acid	fabHF	24,684 bp	1,080,144–1,104,828	Bacteria	+	+	+	+
Molybdenum cofactor	Putative NRPS	metBC, galE	17,703 bp	1,144,555–1,162,258	Bacteria	+	+	−	−
Iturin	TransATPKS-NRPS	xynD, ituABCD, yxjCDEF	44,809 bp	1,883,810–1,928,619	Fungi	+	+	+	+
Amylolysin	Lantipeptide	amlFEKRAMT	9,630 bp	1,194,266–1,203,896	Gram-positive bacteria	+	+	+	−
Amylocyclicin	Bacteriocin-NRPS	acnBACDEF	4,171 bp	3,044,117–3,048,288	Gram-positive bacteria	+	+	+	−