Table 3.
Glucose increased DBMSC expression of genes with antioxidant, anti-inflammatory, anti-chemoattractant, and antimicrobial properties. DBMSCs were untreated (DBMSC) or treated with 200 mM glucose (TDBMSC) for 72 h
| # | Gene symbol | Gene full name | DBMSC Mean ΔΔ−2 values |
TDBMSC Mean ΔΔ−2 values |
Fold change (TDBMSC vs. DBMSC) p < 0.05 |
Biological properties | |
|---|---|---|---|---|---|---|---|
| 1 | GPX2 | Glutathione peroxidase 2 | 1 | 5 | 1 fold | ↑ |
Anti-oxidant property 2. Anti-inflammatory property |
| 2 | GPX3 | Glutathione peroxidase 3 | 1 | 16 | 16 fold | ↑ | |
| 3 | GPX4 | Glutathione peroxidase 4 | 1 | 60 | 60 fold | ↑ | |
| 4 | GPX7 | Glutathione peroxidase 7 | 1 | 4 | 4 fold | ↑ | |
| 5 | UCP2 | Uncoupling protein 2 | 1 | 7 | 7 fold | ↑ | |
| 6 | SEPP1 | Selenoprotein P, plasma, 1 | 1 | 10 | 10 fold | ↑ | |
| 7 | PRDX1 | Peroxiredoxin 1 | 1 | 1.5 | 1.5 fold | ↑ | Anti-oxidant property |
| 8 | PRDX4 | Peroxiredoxin 4 | 1 | 2.52 | 2.52 fold | ↑ | |
| 9 | PRDX5 | Peroxiredoxin 5 | 1 | 2.63 | 2.63 fold | ↑ | |
| 10 | PRDX6 | Peroxiredoxin 6 | 1 | 40 | 40 fold | ↑ | |
| 11 | TPO | Thyroid peroxidase | 1 | 2.48 | 2.48 fold | ↑ | |
| 12 |
TFII-I (GTF2I) |
General transcription factor 2I | 1 | 60 | 60 fold | ↑ | |
| 13 | BNIP3 | BCL2/adenovirus E1B 19 kDa interacting protein 3 | 1 | 49 | 49 fold | ↑ | |
| 14 | PNKP | Polynucleotide kinase 3’-phosphatase | 1 | 2.75 | 2.75 fold | ↑ | |
| 15 | SOD3 | Superoxide dismutase 3 | 1 | 4.45 | 4.45 fold | ↑ |
Anti-oxidant property Anti-inflammatory property 3. Anti-chemoattractant property |
| 16 | HMOX1 | Heme oxygenase- 1 | 1 | 3.18 | 3.18 fold | ↑ | Anti-inflammatory property |
| 17 | MT3 | Metallothionein 3 | 1 | 124 | 124 fold | ↑ | |
| 18 | GSR | Glutathione reductase | 1 | 2.55 | 2.55 fold | ↑ | |
| 19 | DUSP1 | Dual specificity phosphatase 1 | 1 | 2 | 2 fold | ↑ | |
| 20 | KRT1 | Keratin 1 | 1 | 2618 | 2618 fold | ↑ | |
| 21 | NQO1 | NAD(P)H dehydrogenase, quinone 1 | 1 | 21 | 21 fold | ↑ | |
| 22 | SIRT2 | Sirtuin 2 | 1 | 2.99 | 2.99 fold | ↑ | |
| 23 | SFTPD | Surfactant protein D | 1 | 114 | 114 fold | ↑ |
Anti-inflammatory property 2. Antimicrobial property |
| 24 | MBL2 | Mannose-binding lectin (protein C) 2 | 1 | 6.34 | 6.34 fold | ↑ | |