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. 2020 Mar 24;8:188. doi: 10.3389/fcell.2020.00188

FIGURE 2.

FIGURE 2

Induction of nephropathy in NSG mice by aristolochic acid intoxication. (A) Schematic representation of the experimental design for aristolochic acid nephropathy (AAN) in vivo showing the days of administration of AA or Human bone marrow mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) for 4 weeks (wk). (B) Mice body weight was measured weekly before AA injections for 4 weeks. The body weight is represented as percentage weight change. A two-way analyses of variance (ANOVA) was performed with Bonferroni’s multi comparison test; Data are expressed as mean ± SEM of seven mice per group. **p and ***p < 0.001 AA vs. control. (C) Plasma creatinine and (D) BUN levels in mice treated with vehicle alone or mice injected with AA or AA mice injected with MSC-EVs (n = 7 mice per group). **p < 0.001 AA vs. control and AA + MSC-EVs vs. AA. Data are expressed as mean ± SEM; a one way ANOVA with Bonferroni’s multi comparison test was performed.