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MSC-EVs downregulate pro-fibrotic genes in mice treated with AA. Gene expression levels of α-Sma (A), Col1a1 (B), Tgfb1 (C), and Ltbp1 (D) in mice treated with vehicle alone (control), or mice treated with AA, or AA mice treated with MSC-EVs. Data show mean ± SEM of n = 7 samples per treatment. ∗∗∗p < 0.001 AA vs. control, ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001 AA+MSC−EVs vs. AA. A one way ANOVA with Bonferroni’s multi comparison test was performed.
