FIGURE 3.

Proposed model for OMV-mediated iron acquisition. Here it is proposed that a soluble protein, TseF, is exported and accumulates on the surface of OMVs containing the QS molecule PQS-Fe³⁺. The TseF protein interacts with cell-surface receptors to facilitate iron uptake into the cell, panel A. AS shown in panel B, mutants lacking the gene (blue) show a severe growth inhibition which can be recovered through supplementation with OMVs containing TseF protein (red). Reproduced with permission from Lin et al. (2017).