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. 2020 Mar 24;11:479. doi: 10.3389/fimmu.2020.00479

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Copyright © 2020 Graham, Eisenhauer, Diehl, Pierce, Whitehead, Durbin, Kirkpatrick, Sette, Weiskopf, Boyson and Botten.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Memory CD4⁺ T cell populations in the setting of protective DENV vaccination in CIR287 individuals. (A) ICS was used to measure the frequency of all CD4⁺ T cells exhibiting different memory T cell phenotypes (naïve, CD45RA⁺CCR7⁺; T_CM, CD45RA⁻CCR7⁺; T_EM, CD45RA⁻CCR7⁻; or T_EMRA, CD45RA⁺CCR7⁻) in CIR287 vaccinees following DLAV vaccination on day 0 and DENV2Δ30 (Tonga/74) challenge on day 180 post-vaccination. (B) Shows the frequency of IFN-γ⁺CD4⁺ T cells that exhibited different memory phenotypes following stimulation with the DENV CD4 MP. Mean values ± SEM are shown for the eight CIR287 individuals examined. Note that the time of DENV2Δ30 (Tonga/74) challenge (day 180 post-vaccination) is shown in each graph with a red arrow.