Table 4.
Multiple linear regression on the changes of serum mineral and albumin concentrations after HDF conversion in hemodialysis patients
| Laboratory measure | Patient groups | Changes after conversion | Univariate analysis | Multivariate analysisa | ||
|---|---|---|---|---|---|---|
| Unstandardized β (95% CI) | P value | Unstandardized β (95% CI) | P value | |||
| Calcium (mg/dL) | HD group | -0.5 ± 0.8 | Reference | Reference | ||
| OL-HDF group | 0.4 ± 0.7 | 0.96 (0.70, 1.23) | < 0.001 | 1.02 (0.75, 1.30) | < 0.001 | |
| Phosphorus (mg/dL) | HD group | 0.2 ± 1.5 | Reference | Reference | ||
| OL-HDF group | 0.5 ± 1.9 | 0.32 (-0.23, 0.88) | 0.253 | 0.52 (-0.05, 0.1.08) | 0.072 | |
| Ca×P (mg2/dL2) | HD group | -1.2 ± 13.2 | Reference | Reference | ||
| OL-HDF group | 8.9 ± 22.8 | 10.1 (4.6, 15.6) | < 0.001 | 12.1 (6.5, 17.7) | < 0.001 | |
| iPTH (pg/mL) | HD group | 119 ± 230 | Reference | Reference | ||
| OL-HDF group | 107 ± 258 | -11.7 (-93.1, 69.7) | 0.777 | -35.7 (-115.2, 43.7) | 0.376 | |
| Albumin (g/dL) | HD group | -0.1 ± 0.3 | Reference | Reference | ||
| OL-HDF group | 0.1 ± 0.3 | 0.20 (0.09, 0.30) | < 0.001 | 0.19 (0.08, 0.30) | < 0.001 | |
Data regarding the changes of the variables are expressed as mean ± standard deviation.
CI, confidence interval; HD, hemodialysis; HDF, hemodiafiltration; iPTH, intact-parathyroid hormone; OL-HDF, online-HDF.
a
Adjusted for age, sex, etiology of end-stage renal disease, time on dialysis, single-pool Kt/V, and high sensitivity C-reactive protein (hs-CRP).