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. 2020 Mar 24;10:354. doi: 10.3389/fonc.2020.00354

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Copyright © 2020 Agulnik, Gossett, Carrillo, Kang and Morrison.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The predicted PEWS-Like-Score (PEWS-LS) over time prior to deterioration event in hospitalized pediatric hematology-oncology patients. Trends in PEWS-LS prior to PICU admission were analyzed using a generalized estimating equation (GEE) Poisson model implemented in the GLIMMIX procedure of SAS (empirical option) with time as a restricted cubic spline with 4 knots (−11.5, −7.75, −4.25, and −0.5 h), CD as binary variables, and the two-way interaction of time and CD as predictors. Both time (p < 0.001) and CD (p < 0.001) were significant predictors of PEWS-LS, but the two-way interaction was not significant (p = 0.26). At time of PICU transfer or intervention, the predicted mean PEWS-LS was 2.95 (95% CI 2.63, 3.31) for events without CD, and 3.81 (3.53, 4.11) for events with CD. Thus, the predicted PEWS-LS was 0.86 points higher in events with CD at the start of the event, p = 0.0003.