Table 2.
Critical deterioration in hospitalized pediatric hematology-oncology patients.
| Characteristic | Critical deterioration n = 92 | Not critical deterioration n = 92 | p-value |
|---|---|---|---|
| Sex (M), n (%) | 48 (52.2%) | 55 (59.8%) | 0.299a |
| Age (years), median (IQR) | 12.5 (4.7, 16.1) | 5.2 (2.1, 14.5) | 0.002b |
| Primary diagnosis, n (%) | 0.564c | ||
| Hematologic malignancy | 51 (55.4%) | 42 (45.7%) | |
| Solid tumor | 32 (34.8%) | 39 (42.4%) | |
| Benign hematology | 6 (6.5%) | 6 (6.5%) | |
| Other | 3 (3.3%) | 5 (5.4%) | |
| Post-HCT, n (%) | 0.709c | ||
| Auto | 22 (23.9%) | 18 (19.6%) | |
| Allo | 4 (4.3%) | 3 (3.3%) | |
| No | 66 (71.7%) | 71 (77.2%) | |
| Days from hospital admission to deterioration event, median (IQR) | 3.3 (1.1, 14.4) | 3.1 (1.3, 9.5) | 0.757b |
| ICU admission category, n (%) | <0.001c | ||
| Respiratory | 41 (44.6%) | 44 (47.8%) | |
| Cardiovascular | 38 (41.3%) | 12 (13.0%) | |
| Neurologic | 7 (7.6%) | 9 (9.8%) | |
| Fluid/electrolyte | 1 (1.1%) | 4 (4.3%) | |
| Other | 5 (5.4%) | 23 (25.0%) | |
| Interventions, n (%) | |||
| HFNC | 36 (39.1%) | 34 (37.0%) | 0.761a |
| CPAP or BiPAP | 26 (28.3%) | 7 (7.6%) | <0.001a |
| Invasive mechanical ventilation | 46 (50.0%) | 14 (15.2%) | <0.001a |
| Vasoactive infusions | 57 (62.0%) | 7 (7.6%) | <0.001a |
| Dialysis | 12 (13.0%) | 5 (5.4%) | 0.075a |
| CPR | 8 (8.7%) | 1 (1.1%) | 0.035c |
| ICU LOS, median (IQR) | 4.1 (1.8,10.1) | 2.6 (1.0,5.5) | 0.015b |
| ICU-free days, median (IQR) | 21 (8,25) | 24 (18, 26) | 0.011b |
| Hospital LOS, median (IQR) | 20.7(10.2,40.9) | 14.4(7.8,34.4) | 0.119b |
| Vasoactive-free days, median (IQR) | 27(25, 28) | 28(28, 28) | <0.001b |
| Ventilator-free days, median (IQR) | 25 (12.5, 28) | 28(28,28) | <0.001b |
| Mortality, n (%) | 16 (17.4%) | 7 (7.6%) | 0.045a |
| Critical Deterioration n = 89 | Not Critical Deterioration n = 90 | ||
| PIM2, median (IQR) | 4.1(1.2,6.7) | 1.1(0.9,4.2) | <0.001b |
| PRISM 3, median (IQR) | 9.0(5.0,14.0) | 5.0(0.0,10.0) | <0.001b |
BiPAP, Bilevel Positive Airway Pressure; CPAP, Continuous Positive Airway Pressure; CPR, Cardiopulmonary Resuscitation; HCT, Hematopoietic Cell Transplant; HFNC, High Flow Nasal Cannula; IQR, Inter-Quartile Range; LOS, Length of Stay; PICU, Pediatric Intensive Care Unit; PIM, Pediatric Index of Mortality; PRISM, Pediatric Risk of Mortality.
a
Chi-squared,
b
Wilcoxon,
c
Fisher Exact.