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. 2020 Mar 24;8:237. doi: 10.3389/fbioe.2020.00237

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Copyright © 2020 Sun, Zhang, Zhang, Wang, Pan, Liu, Li, Chen, Chang and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The in vivo long-toxicity evaluation of S. 2973 and ALG-S2973. Each group contained three mice. (A) The schedule of animal experiments for toxicity evaluation. (B) Photos of the injection site of BALB/c mice. (C) Detection of immune factors of mice with different treatments at the 1st, 4th, and 7th day. (D) Hematological index of the mice with different treatments at the 1st, 7th, and 21st day. * p < 0.05, ** p < 0.01 compared with untreated group by Student’s t-test. ALG-S2973, hydrogels packaging S. 2973.