FIGURE 6.

In vivo investigation of anti-tumor effects based on ALG-MI-S2973. Each group contained five mice. (A) Schematic diagram of animal experiments. (B) Viability measurement of S. 2973 in tumor sections using fluorescence imaging excited by 561 nm. (C,D) Body weight changes and tumor growth curves of control and 4T1 tumor-bearing mice with different treatments. ** p < 0.01 compared with untreated group by Student’s t-test. (E,F) Volumes and weight of tumors from 4T1 tumor-bearing mice with different treatments; (G) Tumor inhibition rates of different treatments. (H) H&E, TUNEL and immunohistochemical staining of HIF-1α protein in tumor tissues from 4T1 tumor-bearing mice with different treatments. ALG-MI, hydrogels packaging MSN-ICG; ALG-MI-S2973, hydrogels packaging MSN-ICG and S. 2973.