Figure 2.

Properties of mitochondrial respiration were unaltered in fibroblasts of Gilles de la Tourette syndrome (GTS) patients with and without IMMP2L deletions. (A) Respiration overview of groups. (B) Basal respiration as determined as initial resting consumption of oxygen. (C) ATP turnover as measured as a decrease in oxygen consumption after addition of oligomycin. (D) Reserve respiratory capacity as measured as a percentage of basal respiration, after addition of FCCP. The similarity between the groups was also present in whole-cell ATP levels. (E) Mean percentage ± SD of whole-cell ATP presented for each subject (left) and the three groups (right). Black stars mark non-GTS individuals with IMMP2L deletions. All values are normalized to the mean of the healthy control cells within each experimental replica. Each bar represents at least three independent experiments.