Table 3.
Permeability Parameters of 5-FU on different animal skin (cow, goat, and rat).
| Steady-state flux (Jss) (µg/cm2/h) |
Permeability coefficient (KP) (µg × 10–2) |
Enhancement Ratio (Er) |
|||||||
|---|---|---|---|---|---|---|---|---|---|
| Skin Model | 5-FU-S (Control) | 5-FU-NE | 5-FU-NE-Gel | 5-FU-S (Control) | 5-FU-NE | 5-FU-NE-Gel | 5-FU-S (Control) | 5-FU-NE | 5-FU-NE-Gel |
| Cow Skin | 0.957 ± 0.41 | 8.174 ± 0.63 | 9.851 ± 0.84 | 0.0957 ± 0.003 | 0.8174 ± 0.012 | 0.9851 ± 0.016 | – | 8.54 | 10.29 |
| Goat Skin | 0.957 ± 0.40 | 8.212 ± 0.64 | 9.895 ± 0.85 | 0.0957 ± 0.003 | 0.8212 ± 0.013 | 0.9895 ± 0.018 | – | 8.58 | 10.34 |
| Rat Skin | 1.350 ± 0.55 | 10.345 ± 0.97 | 12.0244 ± 1.12 | 0.1350 ± 0.007 | 1.0345 ± 0.061 | 1.2024 ± 0.073 | – | 7.66 | 8.91 |