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. 2020 Mar 24;11:512. doi: 10.3389/fimmu.2020.00512

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Copyright © 2020 Wight, Kang, Evanko, Harten, Chang, Pearce, Allen and Frevert.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Versican increases in the extracellular matrix (ECM) as part of the early inflammatory response. Immune cells invade the tissue from the blood stream and interact with specific ECM components including versican, versican fragments such as versikine (generated by versicanases), and other ECM components that associate with versican. This interaction may involve receptors on the immune cells such as CD44, P-selectin glycoprotein 1 (PSGL-1), receptor for hyaluronan-mediated motility (RHAMM), and toll-like receptors (TLRs). This interaction impacts several aspects of immune cell activation as part of the immune and inflammatory response.