Table 2.
Efficacy by Central Radiographic Assessment.
| All patients N = 339 | DLL3-high N = 238 | DLL3-positive N = 287 | |
|---|---|---|---|
| Primary endpoints | |||
| Objective response rate, n (%) | 42 (12.4) | 34 (14.3) | 38 (13.2) |
| (95% CI) | (9.1–16.4) | (10.1–19.4) | (9.5–17.7) |
| Overall survival, median (mo) | 5.6 | 5.7 | 5.8 |
| (95% CI) | (4.9–6.1) | (4.9–6.7) | (5.1–6.7) |
| Secondary endpoints | |||
| Duration of objective response, median (mo) | 4.0 | 3.7 | 3.7 |
| (95% CI) | (3.0–4.2) | (2.9–4.2) | (2.9–4.2) |
| Progression-free survival, median (mo) | 3.5 | 3.8 | 3.8 |
| (95% CI) | (3.0–3.9) | (3.2–4.1) | (3.2–4.0) |
| Disease control rate, n (%) | 236 (69.6) | 175 (73.5) | 206 (71.8) |
| (95% CI) | (64.4–74.5) | (67.4–79.0) | (66.2–76.9) |
Abbreviations: CI, confidence interval; DLL3, delta-like 3 protein; mo, months.