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. Author manuscript; available in PMC: 2020 Mar 31.
Published in final edited form as: Clin Cancer Res. 2019 Sep 10;25(23):6958–6966. doi: 10.1158/1078-0432.CCR-19-1133

Table 2.

Efficacy by Central Radiographic Assessment.

All patients N = 339 DLL3-high N = 238 DLL3-positive N = 287
Primary endpoints
 Objective response rate, n (%) 42 (12.4) 34 (14.3) 38 (13.2)
 (95% CI) (9.1–16.4) (10.1–19.4) (9.5–17.7)
 Overall survival, median (mo) 5.6 5.7 5.8
 (95% CI) (4.9–6.1) (4.9–6.7) (5.1–6.7)
Secondary endpoints
 Duration of objective response, median (mo) 4.0 3.7 3.7
 (95% CI) (3.0–4.2) (2.9–4.2) (2.9–4.2)
 Progression-free survival, median (mo) 3.5 3.8 3.8
 (95% CI) (3.0–3.9) (3.2–4.1) (3.2–4.0)
 Disease control rate, n (%) 236 (69.6) 175 (73.5) 206 (71.8)
 (95% CI) (64.4–74.5) (67.4–79.0) (66.2–76.9)

Abbreviations: CI, confidence interval; DLL3, delta-like 3 protein; mo, months.