Figure 1.

Acvr1^G328V Causes Neurological Anomalies and Oligodendroglial Cell Expansion

(A) Schematic of the Acvr1^floxG328V allele, and sequencing chromatogram from an Acvr1^floxG328V/+ (G328V) mouse, showing the G→V substitution.

(B) Survival curves of Acvr1^floxG328V/+;Olig2^Cre/+ mice and their littermates.

(C) Snapshot of a video recording of a Acvr1^floxG328V/+;Olig2^Cre/+ mouse experiencing spasms and motor anomalies.

(D) Representative images of tdTomato-expressing cells in the brainstem of mice with the indicated genotypes, at postnatal day 7 (P7) and 21 (P21). Scale bars, 100 μm.

(E) Quantification of the data shown in (D). Each dot represents an individual animal (two to four sections measured per mouse). Horizontal bars represent the mean. ^∗p < 0.05; assessed by unpaired t test.

See also Figure S1 and Video S1.