Skip to main content
. Author manuscript; available in PMC: 2020 Mar 31.
Published in final edited form as: Clin Sci (Lond). 2018 Aug 16;132(15):1711–1723. doi: 10.1042/CS20180337

Figure 2. Inhibition of immunoproteasomes down-regulates antiviral genes and increases viral load in human tracheobronchial epithelial (HTBE) cells.

Figure 2.

HTBE cells (n=4 subjects, as represented by different color symbols) grown at ALI were pre-treated with ONX-0914 for 2 h prior to RV16 infection or 0.25% BSA-PBS treatment (control, CTRL). Cells were harvested after 48 h of infection for measurement of antiviral genes MX1 (A) and OAS1 (B) and RV load (C) by RT-PCR and were normalized to GAPDH gene. (D) Densitometry of LMP2 and LMP7 proteins and representative Western blot images from two subjects. Data were presented as means ± S.E.M. and analyzed using ANOVA.