Figure 6. LMP2 knockout (KO) mice are more susceptible to RV infection than the WT C57BL/6 (C57 WT) mice.
Mice were intranasally inoculated with PBS or RV1B at 107 PFU/mouse for 24 h. (A) – LMP2 mRNA levels were measured in the left lung lobe by RT-PCR and was normalized to 18S gene. (B) – RV load was measured in BAL fluid by RT-PCR. Total (C) and percentage (D) of neutrophils were counted in BAL. n=7–15 mice per group. Data were presented as medians and analyzed by the Kruskal–Wallis test (A,C,D) or the Mann–Whitney test (B).