Table 5.
Multiple Imputation results from FOM1 and FOM2 Clinic. Mean Difference in Z-Scores between BMD and BA Measures in ALSPAC Mothers with lifetime AN-R or AN-BP diagnoses.
| FOM1 Clinic N = 3440 | AN_R (N = 19) | AN_BP (N = 29) | HC (N = 2942) | |||
|---|---|---|---|---|---|---|
| Total Body Minus Head | ß (95% CI) | p | ß (95% CI) | p | Ref. | |
| Crude Analysis | BMD | −0.45 (−0.79; 0.12) | 0.007 | −0.24 (−0.65; 0.18) | 0.260 | |
| BA | −0.32 (−0.82; 0.18) | 0.205 | −0.27 (−0.61; 0.05) | 0.106 | ||
| Adjusted | BMD | −0.37 (−0.62; −0.12) | 0.004 | −0.13 (−0.46; 0.19) | 0.426 | |
| BA | −0.23 (−0.58; 0.12) | 0.197 | −0.13 (−0.41; 0.14) | 0.333 | ||
| Adjusted + Lowest Ever BMI | BMD | −0.15 (−0.42; 0.12) | 0.269 | 0.07(−0.28; 0.43) | 0.700 | |
| BA | 0.12 (−0.28; 0.52) | 0.560 | 0.15 (−0.14; 0.45) | 0.311 | ||
| FOM2 Clinic N = 2256 | AN_R (N = 19) | p | AN_BP (N = 29) | p | HC (N = 1948) | |
| Total Hip | ß (95% CI) | ß (95% CI) | Ref. | |||
| Crude Analysis | BMD | −0.47 (−0.76; −0.19) | 0.001 | −0.35 (−0.79; −0.08) | 0.114 | |
| BA | −0.37 (−0.82; 0.07) | 0.101 | −0.16 (−0.59; 0.26) | 0.450 | ||
| Adjusted | BMD | −0.51 (−0.82; −0.21) | 0.001 | −0.38 (−0.83; 0.06) | 0.093 | |
| BA | −0.21 (−0.54; 0.14) | 0.246 | 0.09 (−0.27; 0.46) | 0.601 | ||
| Adjusted + Lowest Ever BMI | BMD | −0.09 (−0.46; 0.27) | 0.602 | 0.04 (−0.42; 0.52) | 0.836 | |
| BA | −0.03 (−0.41; 0.34) | 0.859 | 0.27 (−0.11; 0.66) | 0.165 | ||
BMD = Bone Mineral Density; BA = Bone Area; FOM1 = Focus on Mothers Clinic 1; FOM2 = Focus on Mothers Clinic.
Adjusted = Adjusted for Confounders including: Ethnicity, Educational Level, Height2, BA *In Analysis of BA, BA was excluded from the Confounding set. Bold numbers which are statistically significant.