Lee 2009.
| Methods | Generation of allocation sequence: Sealed opaque envelopes, randomisation blocks of 10 Allocation concealment: No stated. Blinding: Not stated. Inclusion of all randomised patients: Yes |
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| Participants | Number: 1000 (460M: 540F) Age: CAC group: 52.6 +/‐ 14.0 years. RC group 52.6 +/‐ 13.8 years Source: 2 regional endoscopy centres. Inclusion criteria: Aged 18 years or over, undergoing first colonoscopy and could provide written consent. Exclusion criteria: Prior colonoscopy or prior colonic surgery (except appendicectomy), having colonic stricture or obstructing tumour. Acute surgical conditions or acute GI bleeding. |
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| Interventions | Colonoscope: Regular colonoscopes without variable stiffness: CF‐240 or CF‐Q240 (Olympus Medical Systems, Tokyo, Japan). Bowel preparation: 3 day of low‐residue diet. Either 4L polyethylene glycol (Klean‐Pred, Harefield, UK) or 90ml phosphosoda (Fleet, CB Fleet, Virginia, USA). Intra‐procedure medication: Diazepam 0.05mg/kg IV, pethidine 0.25mg/kg IV. Endoscopist experience: 8 had at least 5 years experience and >3000 cases. 3 had at least 2 years experience and >1000 cases. Caps: Mucosectomy cap MAJ‐665 or MH‐596 (Olympus Medical Systems Corp). |
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| Outcomes | Included in review: Caecal intubation rate, caecal intubation time, Polyp detection, Pain during procedure Excluded from review: Analgesia/sedation requirements? Complications. |
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| Notes | Location: China Source of funding: Not stated Attempts to clarify information: Not necessary Language of Publication: Englilsh |
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| Risk of bias | ||
| Bias | Authors' judgement | Support for judgement |
| Random sequence generation (selection bias) | Low risk | Sealed envelopes |
| Allocation concealment (selection bias) | High risk | Not concealed as not blinded |
| Blinding (performance bias and detection bias) All outcomes | High risk | Not stated but endoscopist not blinded |
| Incomplete outcome data (attrition bias) All outcomes | Low risk | All randomised patients included in analysis |
| Selective reporting (reporting bias) | Low risk | Appropriate outcomes reported |
| Other bias | Unclear risk | Source of funding not stated. |