Chen 1997b.

Methods	RCT 1993 to 1994
Participants	60 patients Stage IIB to IIIB
Interventions	Radiotherapy plus hypothermia versus concomitant chemoradiotherapy (Cisplatin) plus hypothermia
Outcomes	Survival, disease free survival, local and distant recurrence, acute toxicity, late toxicity
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Data checks on IPD provided suggest adequate sequence generation
Allocation concealment (selection bias)	Low risk	Sealed envelope
Blinding (performance bias and detection bias) All outcomes	High risk	Trial was not blinded due to nature of treatment interventions
Incomplete outcome data (attrition bias) All outcomes	Low risk	IPD provided for all outcomes. NB. Substantial proportion of data missing for late toxicity outcomes
Selective reporting (reporting bias)	Low risk	N/A (IPD supplied for all outcomes)
Other bias	Low risk	Data checks on IPD provided suggest study is free of follow‐up bias