Keys 1999.

Methods	RCT 1993‐1997
Participants	374 patients Stage IB (bulky)
Interventions	Radiotherapy plus hysterectomy versus concomitant chemoradiotherapy (Cisplatin) plus hysterectomy
Outcomes	Survival, disease‐free survival, local and distant recurrence, acute toxicity
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Data checks on IPD provided suggest adequate sequence generation
Allocation concealment (selection bias)	Low risk	Central telephone
Blinding (performance bias and detection bias) All outcomes	High risk	Trial was not blinded due to nature of treatment interventions
Incomplete outcome data (attrition bias) All outcomes	Low risk	IPD provided for all outcomes except late toxicity
Selective reporting (reporting bias)	Low risk	N/A (IPD supplied for all outcomes except late toxicity)
Other bias	Low risk	Data checks on IPD provided suggest study is free of follow‐up bias