Lanciano 2005a.
Methods | RCT 1997 to 1998 |
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Participants | 50 patients Stage IIB, IIIB, IVA |
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Interventions | Radiotherapy versus concomitant chemoradiotherapy (Cisplatin) | |
Outcomes | Survival, disease‐free survival, local and distant recurrence, acute toxicity | |
Notes | 3‐arm trial with Lanciano (b) NB Control arm is the same for both trials | |
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Low risk | Data checks on IPD provided suggest adequate sequence generation |
Allocation concealment (selection bias) | Low risk | Cental telephone |
Blinding (performance bias and detection bias) All outcomes | High risk | Trial was not blinded due to nature of treatment interventions |
Incomplete outcome data (attrition bias) All outcomes | Low risk | IPD provided for all outcomes except late toxicity |
Selective reporting (reporting bias) | Low risk | N/A (IPD supplied for all outcomes except late toxicity) |
Other bias | Low risk | Data checks on IPD provided suggest study is free of follow‐up bias |