Lanciano 2005b.

Methods	RCT 1997 to 1998
Participants	51 Patients Stage IIB, IIIB, IVA
Interventions	Radiotherapy versus concomitant chemoradiotherapy (5‐FU)
Outcomes	Survival, disease‐free survival, local and distant recurrence, acute toxicity
Notes	3‐arm trial with Lanciano (b) NB Control arm is the same for both trials
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Data checks on IPD provided suggest adequate sequence generation
Allocation concealment (selection bias)	Low risk	Central telephone
Blinding (performance bias and detection bias) All outcomes	High risk	Trial was not blinded due to nature of treatment interventions
Incomplete outcome data (attrition bias) All outcomes	Low risk	IPD provided for all outcomes except late toxicity
Selective reporting (reporting bias)	Low risk	N/A (IPD supplied for all outcomes except late toxicity)
Other bias	Low risk	Data checks on IPD provided suggest study is free of follow‐up bias