Morris 1999.
Methods | RCT 1990 to 1997 |
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Participants | 403 patients Stage IB or IIA (>4cm or positive nodes only ); IIB to IVA |
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Interventions | Extended field radiotherapy versus concomitant chemoradiotherapy (Cisplatin, 5‐FU) | |
Outcomes | Survival, disease‐free survival, local and distant recurrence, acute toxicity, late toxicity | |
Notes | Included in sensitivity analysis only as control arm RT differs to that on treatment arm | |
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Low risk | Data checks on IPD provided suggest adequate sequence generation |
Allocation concealment (selection bias) | Low risk | Central telephone |
Blinding (performance bias and detection bias) All outcomes | High risk | Trial was not blinded due to nature of treatment interventions |
Incomplete outcome data (attrition bias) All outcomes | Low risk | IPD provided for all outcomes |
Selective reporting (reporting bias) | Low risk | N/A (IPD supplied for all outcomes) |
Other bias | Low risk | Data checks on IPD provided suggest study is free of follow‐up bias |