Thomas 1998b.
Methods | RCT 1987 to 1995 |
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Participants | 118 women Stage IB (>5cm) to IVA |
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Interventions | Hyperfractionated radiotherapy versus concomitant chemotherapy (5‐FU )and hyperfractionated radiotherapy | |
Outcomes | Survival, disease‐free survival, local and distant recurrence, acute toxicity, late toxicity | |
Notes | 4‐arm trial with Thomas (a) | |
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Low risk | Data checks on IPD provided suggest adequate sequence generation |
Blinding (performance bias and detection bias) All outcomes | High risk | Trial was not blinded due to nature of treatment interventions |
Incomplete outcome data (attrition bias) All outcomes | Low risk | IPD provided for all outcomes. NB. Substantial proportion of data missing for late toxicity outcomes |
Selective reporting (reporting bias) | Low risk | N/A (IPD supplied for all outcomes) |
Other bias | Low risk | Data checks on IPD provided suggest study is free of follow‐up bias |