Thomas 1998b.

Methods	RCT 1987 to 1995
Participants	118 women Stage IB (>5cm) to IVA
Interventions	Hyperfractionated radiotherapy versus concomitant chemotherapy (5‐FU )and hyperfractionated radiotherapy
Outcomes	Survival, disease‐free survival, local and distant recurrence, acute toxicity, late toxicity
Notes	4‐arm trial with Thomas (a)
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Data checks on IPD provided suggest adequate sequence generation
Blinding (performance bias and detection bias) All outcomes	High risk	Trial was not blinded due to nature of treatment interventions
Incomplete outcome data (attrition bias) All outcomes	Low risk	IPD provided for all outcomes. NB. Substantial proportion of data missing for late toxicity outcomes
Selective reporting (reporting bias)	Low risk	N/A (IPD supplied for all outcomes)
Other bias	Low risk	Data checks on IPD provided suggest study is free of follow‐up bias