| Issues |
| • Blood brain barrier |
| • Diversity of cell types and complex neuronal networking |
| • Choice of disease model, duration of treatment, choice of target(s) |
| Possible delivery modalities |
| • Intracranial injections |
| • Transfection (oncoretrovirus, lentivirus, adenovirus, adeno associated virus, others) |
| • Electroporation |
| • Osmotic minipump infusions, i.c.v. or intrathecal |
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