Table 1.

Examples of neurological disorders and their respective molecular target(s) for RNAi

Neurological disorder	Mutated protein(s)
Amyotrophic lateral sclerosis	Cu/Zn superoxide dismutase
Spinocerebellar ataxia type 1	Ataxin-1
Huntington's disease	Huntingtin
Spinobulbar muscular atrophy (Kennedy's disease)	Androgen receptor
Familial Alzheimer's disease	Amyloid precursor protein, presenilin 1 or 2
Parkinsonian frontotemporal dementia	Tau
DYT1 dystonia	TorsinA
Spinal muscular atrophy	Survival motor neuron protein
Machado-Joseph disease	MJD1
Prion-based disease	Prion
Chronic pain	Various ligand or ion-gated channels