Table 1.
Technology 1 | Technology 2 | Technology 3 | |
---|---|---|---|
Name of specific type of technology |
CADDa based on TCMb |
FAC–MSc for screening |
MIP-SPEd for screening and separating |
Names of specific technologies with associated companies and company Web sites | Accelrys, Inc. http://www.accelrys.com/ | Applied Biosystems http://www.appliedbiosystems.com/ | Applied Biosystems http://www.appliedbiosystems.com/ |
Neotrident Technique Ltd. http://www.neotrident.com/ |
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Pros | Virtual screening based on TCM database has higher hit rate than that based on chemical database | Only for screening, higher hit rate | Combining the screening, separating and identifying on one single step |
No false leads |
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Cons |
High throughput |
Relatively high throughput |
Relatively high throughput |
References | [9, 10] | [19, 20, 23] | [27, 29] |
Computer-aided drug design.
Traditional Chinese medicine.
Frontal affinity chromatography with mass spectrometry.
Molecularly imprinted polymers in solid phase extraction.