(a) Volume overload |
Arterio-venous shunt formation |
[8] |
Aortic regurgitation
|
[9, 10]
|
(b) Models of ventricular hypertrophy |
Chronic AV block |
[12] |
Chronic infusion of angiotensin |
[18] |
LV pressure overload |
|
Aortic constriction |
[13, 14, 15] |
Nephrectomy (hypertension) |
[16, 17] |
RV pressure overload |
|
Pulmonary artery constriction – adult |
[19] |
Pulmonary artery constriction – young |
[20] |
Monocrotaline-induced pulmonary hypertension
|
[21]
|
(c) Ischemic heart disease models |
Myocardial infarction in the rabbit |
|
Coronary artery occlusion |
[23, 24] |
Myocardial ischemia followed by reperfusion |
[27] |
Intracoronary microsphere embolization |
[28] |
Direct current shock |
[30] |
Hibernating myocardium |
|
Coronary artery ligation |
[31] |
Cellular model
|
[32]
|
(d) Heart failure |
Adriamycin cardiomyopathy |
[37, 38, 39] |
High-dose catecholamines |
[42] |
Pacing-induced heart failure |
[44, 45, 46, 47] |
Combined pressure and volume overload
|
[5, 52, 54, 59, 61]
|
(e)In vivoarrhythmia models
|
Torsades des pointes |
[62, 63, 64, 65] |
Atrial fibrillation |
|
Isolated rabbit atria prep |
[67, 68, 69] |
Ventricular tachypacing-induced HF
|
[71]
|
(f) Transgenic rabbit models of heart disease |
Long QT syndrome |
[72] |
Hypertrophic cardiomyopathy |
[73, 74] |
Gsα overexpression |
[75] |
Phospholamban overexpression
|
[76]
|
(g) Other rabbit cardiac models |
Myocarditis |
|
Viral (coronavirus and coxsackie virus) |
[77, 78] |
Fungal (Cryptococcus) |
[79] |
Parasitic (toxoplasmosis) |
[80] |
Bacterial (streptococci and diphtheria) |
[81, 82] |
Chronic Chagas disease (Trypanosoma cruzi) |
[83, 84] |
Bacterial endocarditis (streptococcus, enterococcus and staphylococcus) |
[85] |
Radiation-induced heart disease |
[87] |