Table 1. CCTA Findings by Sex Among Enrolled Participants.
| Characteristic | Enrolled, No./total No. (%) | P value | |
|---|---|---|---|
| Women (n = 2262) | Men (n = 6256) | ||
| Age at enrollment, median, (IQR), y | 64 (57-70) | 63 (56-69) | .10 |
| CCTA performed | 1524/2262 (67.4) | 4382/6256 (70.0) | .02 |
| CCTA findings | |||
| Vessels ≥50% stenosis by CCTA | |||
| 0 | 352/1022 (34.4) | 378/3353 (11.3) | <.001 |
| 1 | 200/1022 (19.6) | 585/3353 (17.4) | |
| 2 | 212/1022 (2.7) | 869/3353 (25.9) | |
| ≥3 | 258/1022 (25.2) | 1521/3353 (45.4) | |
| Specific native vessels with ≥50% stenosis by CCTA | |||
| LM | 59/1487 (4.0) | 442/4270 (1.4) | <.001 |
| LAD | 760/1342 (56.6) | 3133/4075 (76.9) | <.001 |
| Proximal LAD | 419/1461 (28.7) | 1829/4172 (43.8) | <.001 |
| LCx | 481/1265 (38.0) | 2408/3907 (61.6) | <.001 |
| RCA | 496/1218 (4.7) | 2348/3738 (62.8) | <.001 |
| Vessels ≥70% stenosis by CCTA | |||
| 0 | 452/915 (49.4) | 648/2878 (22.5) | <.001 |
| 1 | 240/915 (26.2) | 903/2878 (31.4) | |
| 2 | 137/915 (15.0) | 740/2878 (25.7) | |
| ≥3 | 86/915 (9.4) | 587/2878 (2.4) | |
| Specific native vessels with ≥70% stenosis by CCTA | |||
| LM | 16/1487 (1.1) | 93/4270 (2.2) | .007 |
| LAD | 464/1254 (37.0) | 2117/3842 (55.1) | <.001 |
| Proximal LAD | 171/1458 (11.7) | 901/4161 (21.7) | <.001 |
| LCx | 304/1221 (24.9) | 1606/3739 (43.0) | <.001 |
| RCA | 294/1158 (25.4) | 1609/3501 (46.0) | <.001 |
| Randomized | 1168/2262 (51.6) | 4011/6256 (64.1) | <.001 |
| Reasons for exclusion from randomizationa | |||
| Nonobstructive CAD on CCTA | 575/1094 (52.6) | 643/2245 (28.6) | <.001 |
| Insufficient ischemia | 465/1094 (42.5) | 885/2245 (39.4) | .09 |
| Unprotected left main ≥50 | 52/1094 (4.8) | 382/2245 (17.0) | <.001 |
| Withdrew consent | 66/1094 (6.0) | 195/2245 (8.7) | .007 |
| Intercurrent event | 10/1094 (.9) | 39/2245 (1.7) | .06 |
| Other | 142/1094 (13.1) | 454/2245 (21.9) | <.001 |
Abbreviations: CAD, coronary artery disease; CCTA, coronary computed tomography angiography; IQR, interquartile range; LAD, left anterior descending; LM, left main; LCx, left circumflex; RCA, right coronary artery.
a
Note that reasons for exclusion are not mutually exclusive.