Table 2. Likelihood of Obstructive CAD by Sex and Stress Test Findings, by Modality, in Enrolled Participants.
| Description | Proportion with ≥50% stenosis, No./total No. (%) | P value | Proportion with ≥70% stenosis, No./total No. (%) | P value | ||
|---|---|---|---|---|---|---|
| Women | Men | Women | Men | |||
| All stress modalities | ||||||
| Meets criteriaa | 774/1024 (75.6) | 3229/3455 (93.5) | <.001 | 597/923 (64.7) | 2771/3200 (86.6) | <.001 |
| Does not meet criteriab | 155/257 (60.3) | 514/666 (77.2) | <.001 | 105/231 (45.5) | 381/600 (63.5) | <.001 |
| Ratio of proportions (95% CI), yes/noc | 1.25 (1.13-1.39) | 1.21 (1.16-1.26) | 1.03 (0.92-1.16) | 1.42 (1.23-1.65) | 1.36 (1.28-1.45) | 1.04 (0.89-1.23) |
| P valuec | NA | NA | .55 | NA | NA | .61 |
| Stress imaging | ||||||
| Meets criteriaa | 572/751 (76.2) | 2278/2410 (94.5) | <.001 | 425/666 (63.8) | 1881/2195 (85.7) | <.001 |
| Does not meet criteriab | 99/165 (60.0) | 319/427 (74.7) | <.001 | 58/144 (40.3) | 215/369 (58.3) | <.001 |
| Ratio of proportions (95% CI), yes/noc | 1.27 (1.11-1.45) | 1.27 (1.20-1.34) | 1.00 (0.87-1.16) | 1.58 (1.29-1.95) | 1.47 (1.35-1.61) | 1.08 (0.86-1.35) |
| P valuec | NA | NA | .96 | NA | NA | .52 |
| Nonimaging | ||||||
| Meets criteriaa | 202/273 (74.0) | 951/1045 (91.0) | <.001 | 172/257 (66.9) | 890/1005 (88.6) | <.001 |
| Does not meet criteriab | 56/92 (60.9) | 195/239 (81.6) | <.001 | 47/87 (54.0) | 166/231 (71.9) | .003 |
| Ratio of proportions (95% CI), yes/noc | 1.22 (1.02-1.45) | 1.12 (1.05-1.19) | 1.09 (0.90-1.32) | 1.24 (1.00-1.53) | 1.23 (1.13-1.34) | 1.01 (0.80-1.26) |
| P valuec | NA | NA | .37 | NA | NA | .96 |
| Nuclear | ||||||
| Meets criteriaa | 326/373 (87.4) | 1482/1551 (95.6) | <.001 | 254/332 (76.5) | 1264/1434 (88.1) | <.001 |
| Does not meet criteriab | 65/110 (59.1) | 227/312 (72.8) | .008 | 41/98 (41.8) | 151/268 (56.3) | .01 |
| Ratio of proportions (95% CI), yes/noc | 1.48 (1.26-1.74) | 1.31 (1.23-1.41) | 1.13 (0.95-1.34) | 1.83 (1.44-2.33) | 1.56 (1.41-1.74) | 1.17 (0.90-1.52) |
| P valuec | NA | NA | .18 | NA | NA | .25 |
| Echo | ||||||
| Meets criteriaa | 206/330 (62.4) | 680/742 (91.6) | <.001 | 139/291 (47.8) | 515/652 (79.0) | <.001 |
| Does not meet criteriab | 28/49 (57.1) | 82/102 (80.4) | .003 | 16/43 (37.2) | 58/89 (65.2) | .002 |
| Ratio of proportions (95% CI), dyes/noc | 1.09 (0.85-1.41) | 1.14 (1.03-1.26) | 0.96 (0.73-1.26) | 1.28 (0.85-1.93) | 1.21 (1.04-1.42) | 1.06 (0.69-1.64) |
| P valuec | NA | NA | .76 | NA | NA | .80 |
| Echo (severe definition) | ||||||
| Meets criteriaa | 133/206 (64.6) | 472/509 (92.7) | <.001 | 87/180 (48.3) | 376/453 (83.0) | <.001 |
| Does not meet criteriab | 101/173 (58.4) | 290/335 (86.6) | <.001 | 68/154 (44.2) | 197/288 (68.4) | <.001 |
| Ratio of proportions (95% CI), yes/noc | 1.11 (0.94-1.30) | 1.07 (1.02-1.12) | 1.03 (0.87-1.22) | 1.09 (0.87-1.38) | 1.21 (1.11-1.33) | 0.90 (0.70-1.16) |
| P valuec | NA | NA | .71 | NA | NA | .42 |
| CMR | ||||||
| Meets criteriaa | 40/48 (83.3) | 116/117 (99.1) | <.001 | 32/43 (74.4) | 102/109 (93.6) | <.001 |
| Does not meet criteriab | 6/6 (100.0) | 10/13 (76.9) | .52 | 1/3 (33.3) | 6/12 (50.0) | >.99 |
| Ratio of proportions (95% CI), yes/noc | NA | NA | NA | 2.23 (0.45-11.17) | 1.87 (1.06-3.30) | 1.19 (0.22-6.58) |
| P valuec | NA | NA | NA | NA | NA | .84 |
Abbreviations: CAD, coronary artery disease; CMR, stress cardiac magnetic resonance imaging; NA, not applicable.
a
Met trial-defined ischemia entry criteria according to the stress core laboratory for the respective stress test modality.
b
Did not meet trial-defined ischemia entry criteria according to the stress core laboratory for the respective stress test modality.
c
P value reported is for the comparison of the ratio of sex-specific rate ratios (women vs men) for assessing the likelihood of any obstructive CAD for participants who did vs did not meet trial-defined stress test criteria (moderate or severe ischemia for stress imaging, severe ischemia for nonimaging stress test, ie, exercise tolerance test).