Table 5.

Genes from selected MHC regions, identified in humans and fish (5, 13)

	Humans	Spotted gar		Atlantic salmon		Shared genes**
MHC I	MHC II	MHC I	MHC II	MHC I	MHC II	MHC I	MHC II***
HLA-G	HLA-DRα	U (3 loci)	Eα (2 loci)	U*	Eα	PSMB8	PBX2
HLA-A	HLA-DRβ	P (3 loci)	Eβ (2 loci)		Eβ	TUBB	TAP1
HLA-E	HLA-DQα	L (2 loci)	A/Bα			FLOT1	RGL2
HLA-C	HLA-DQβ	u.s.	A/Bβ			TCF19	PHF1
HLA-B	HLA-DPα		u.s. α			TAP2	BRD2
	HLA-DPβ					PSMB9	SYNGAP-like
	HLA-DMα					BRD2
	HLA-DMβ					TAPBP
	HLA-Doα					RXRB
	HLA-Doβ					HSD17B8
						PSMB10

u.s. – undefined sequence; PSMB8 – protein-coding gene, proteasome subunit β type-8; TUBB – protein-coding gene, tubulin β-chain; FLOT1 – protein-coding gene, flotillin-1; TCF19 – protein-coding gene, transcription factor 19; TAP2 – protein-coding gene, antigen peptide transporter 2; PSMB9 – protein-coding gene, proteasome subunit β type-9; BRD2 – protein-coding gene, bromodomain-containing protein 2; TAPBP – protein-coding gene, TAP-associated glycoprotein, also known as tapasin; RXRB – gene, retinoid X reflex point β (RXR-β); HSD17B8 – enzyme, oestradiol 17 β-dehydrogenase 8; PSMB10 – protein coding gene, proteasome subunit β type-10; PBX2 – protein-coding gene, pre-B-cell leukaemia transcription factor 2; TAP1 – protein-coding gene, transporter associated with antigen processing 1; RGL2 – protein-coding gene, ral guanine nucleotide dissociation stimulator-like 2; PHF1 – protein-coding gene, PHD finger protein 1; SYNGAP-like – Ras GTPase-activating protein SynGap-like;

^**– selected genes shared by humans (MHC region sized ~ 4Mb) and Salmo salar (MHC I and MHC II), as well as by Danio rerio and Oryzias latipes (MHC I);

^***– genes occurring within sublineage E in Salmonidae

^*– syntenic gene;