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. 2016 Dec 14;15(8):1452–1462. doi: 10.1038/sj.mt.6300186

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Copyright © 2007 The American Society of Gene Therapy. Published by Elsevier Inc. All rights reserved.

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Small interfering RNAs (siRNAs) protect against establishment of hepatitis C virus (HCV) replicon-containing cell clones. (a) Numbers of G418-resistant 2-3c cell clones obtained 3 weeks after cotransfection of 5 μg of Ntat2ANeo or NNeo replicon and 2 μg of each indicated siRNA that is homologous to both HCV replicons (si205, si244, si313) or irrelevant siRNA (siIRR) are expressed relative to 10,000 resistant cell clones obtained after transfection of HCV replicon alone (Ø). Values (means ± SDs of independent transfections) are plotted on a logarithmic scale. (b) The effects of si240-1a or si240-1b treatment on replicon Ntat2ANeo (left) and NNeo (right) are represented separately. Mismatches present at position 18 of the siRNA antisense strand are indicated on top of the bars corresponding to heterologous targets. NTR, nontranslated region.