Table 2.
Effect of siRNAs on hepatitis C virus production
| Virus productiona | ||
|---|---|---|
| siRNA | JFH-1 | JFH-1/C(+)6-1a-1/C(+)6-1a |
| Ø | 8.4 × 103 (100) | 7.1 × 103 (100) |
| siIRR | 7.8 × 103 (93) | 6.6 × 103 (93) |
| si240-1a | 2.9 × 103 (35) | 1.0 × 103 (14) |
| si244 | 5.1 × 103 (61) | 1.1 × 103 (15) |
| si313 | 1.5 × 102 (2) | 3.0 × 102 (4) |
Abbreviations: siIRR, irrelevant siRNA; siRNA, small interfering RNA.
a
Viral titers in the supernatants of HuAP cells transfected with each siRNA and infected with the indicated virus are expressed in focus forming units/ml, as well as, in parentheses (%) relative to virus production from mock-transfected cultures (Ø) set at 100%.