Table 1.
List of Assays Commercially Available for PCR-ESI/MS
| Assay name | Coverage |
|---|---|
| BAC detection assay | Designed to detect all groups of bacteria, including Mycoplasma, Chlamydia, Rickettsia, and Candida species, and antibiotic resistance markers (blaKPC, mecA, vanA, and vanB genes) |
| Biothreat | Designed to detect and identify 17 bacterial and viral biothreat agents and distinguish them from their near neighbors |
| Broad bacteria | Designed to detect and identify all groups of bacteria, including intracellular organisms, such as Mycoplasma, Chlamydia, and Rickettsia, as single organisms or simple mixtures from isolates or high-load samples |
| Broad bacteria | Designed to detect and identify all groups of bacteria, including intracellular organisms, such as Mycoplasma, Chlamydia, and Rickettsia, as single organisms or simple mixtures from isolates |
| Broad fungal | Designed to identify Aspergillus, Bipolaris, Candida, Fusarium, Penicillium, Clavispora, and Cryptococcus species along with common fungi |
| Broad viral I | Designed to detect and identify individual organisms or mixtures of Herpesviridae, human adenovirus, human enterovirus, polyomavirus, and parvovirus directly from samples |
| Clostridium difficile | Designed to rapidly identify C. difficile and the mutations associated with the tcdC locus and NAP-1 strains while simultaneously detecting tcdA, tcdB, cdtA, and cdtB genes |
| Flu detection assay | Detection and characterization of known and newly emerging influenza A, B, and C viruses directly from human, avian, animal, or environmental specimens |
| Foodborne bacteria | Designed to detect and identify several common foodborne bacteria, including Escherichia coli O55:H7 and O157:H7, >250 members of Salmonella enterica serotypes, Shigella, and Listeria species |
| MRSA detection | Genotyping and characterization (mecA, lukS-PV, lukD, tsst-1 and mup genes) of Staphylococcus aureus with a focus on MRSA strains |
| MDR TB | Determination of MDR in Mycobacterium tuberculosis isolates and identification of NTM |
| Pneumococcus serotyping | Identification and characterization of Streptococcus pneumoniae from culture isolates |
| Respiratory virus | Detection and identification of common respiratory viruses, including influenza, respiratory syncytial virus, adenovirus with typing, parainfluenza virus 1 to 4, human metapneumovirus, and coronavirus |
| Vectorborne BPN | Designed to detect and identify bacteria (Francisella, Borrelia, Rickettsia rickettsii, and alphaproteobacteria), protozoa (Babesia), and nematodes (Dirofilaria immitis) transmitted by ticks |
BAC, bacteria, antibiotics, candida; BPN, bacteria, protozoa, nematodes; MDR, multidrug resistant; MRSA, methicillin-resistant S. aureus; NAP, North American pulsed field type; NTM, nontuberculous mycobacteria; TB, Mycobacteria tuberculosis.