Table 1.
Pharmacokinetic parameters of total sera radioactivity after i.v. injection of various doses of 125I-labelled F(ab′)2 in macaques
| Parameters | Unit | Injected dose |
||
|---|---|---|---|---|
| 1 mg/kg | 3 mg/kg | 10 mg/kg | ||
| AUC(0–168 h) | μg Equ h mL− 1 | 159.0 ± 15.2a3,b3 | 446.52 ± 36.0c3 | 1419.9 ± 165.7 |
| AUC(0–∞) | μg Equ h mL− 1 | 170.5 ± 18.0a2,b2 | 471.7 ± 43.3c2 | 1522.4 ± 184.0 |
| AUC(168 h–∞) | μg Equ h mL− 1 | 11.4 ± 4.4a1,b1 | 25.2 ± 7.3c1 | 102.5 ± 31.8 |
| AUC(168 h–∞)% | % | 6.6 ± 2.1 | 5.3 ± 1.0 | 6.7 ± 1.6 |
| MRT (h) | H | 35.7 ± 1.8 | 33.7 ± 1.5 | 36.4 ± 1.7 |
| CL/F | mL kg− 1 h− 1 | 5.9 ± 0.7 | 6.4 ± 0.6 | 6.6 ± 0.9 |
| VSS | mL kg− 1 | 210.8 ± 18.1 | 215.3 ± 10.3 | 241.3 ± 28.2 |
| t1/2 (h) | H | 46.1 ± 3.4 | 41.2 ± 1.2 | 45.9 ± 3.0 |
| Kel | 1/h | 0.0151 ± 0.0011 | 0.0168 ± 0.0005 | 0.0151 ± 0.0010 |
a1, a2 or a3: 1 mg/kg vs 3 mg/kg group; intergroup t-test, p < 0.05, p < 0.01 or p < 0.01, respectively.
b1, b2 or b3: 1 mg/kg vs 10 mg/kg; paring t-test, p < 0.05, p < 0.01 or p < 0.01, respectively.
c1, c2 or c3: 3 mg/kg vs 10 mg/kg; paring t-test, p < 0.05, p < 0.01 or p < 0.01, respectively.