Table 1.
Comparison of IgY and IgG.
| IgY | IgG | |
|---|---|---|
| Species | Birds, reptiles, amphibians and lungfish | Mammals |
| Source | Serum and eggs | Serum |
| Concentration | 100–150 mg/egg (15 mL/yolk) |
200 mg/bleed (40 mL) |
| Molecular weight (kDa) | 180 | 150 |
| Constant domains (Heavy chain) | 4 | 3 |
| Hinge region | No | Yes |
| pH stability | 3.5–11.0 | 2.0–11.0 |
| Heat stability | Up to 70 °C | Up to 75°–80° |
| Proteolytic degradation | Pepsin and papain | Pepsin, papain, trypsin and chymotrypsin |
| Complement binding | No | Yes |
| Rheumatoid factor binding | No | Yes |
| Fc receptor binding | No | Yes |
| Binding to protein A and G | No | Yes |