Table 1.
Mutations found in the entire genome of SARS-CoV-2 strains. The number in the parentheses indicated the location of amino acid in its protein.
| Genomic region | No. nt mutations | Missense mutation | SARV-CoV-2 strain |
|---|---|---|---|
| 5′ UTR | 8 | N/A | |
| ORF1ab polyprotein | 48 | 29 | |
| A (117) → T | USA/CA3/2020/EPI_ISL_408008 USA/CA4/2020/EPI_ISL_408009 |
||
| P (309) → S | France/IDF0515/2020/EPI ISL_408430 | ||
| S (428) → N | USA/CA1/2020/EPI_ISL_406034 | ||
| T (609) → I | USA/CA5/2020/EPI_ISL_408010 | ||
| A (1176) → V | Japan/TY-WK-012/2020/EPI_ISL_408665 | ||
| L (1599) → F | Korea/KCDC03/2020/EPI_ISL_407193 | ||
| I (1607) → V | USA/CA3/2020/EPI_ISL_408008 USA/CA4/2020/EPI_ISL_408009 |
||
| M (2194) → T | Shenzhen/SZTH-004/2020/EPI_ISL_406595 | ||
| L (2235) → I | Wuhan/WH01/2019/EPI_ISL_406798 | ||
| I (2244) → T | Wuhan/IPBCAMS-WH-03/2019/EPI_ISL_403930 | ||
| G (2251) → S | Wuhan/WIV05/2019/EPI_ISL_402128 | ||
| A (2345) → V | Shandong/IVDC-SD-001/2020/EPI_ISL_408482 | ||
| G (2534) → V | Wuhan/IPBCAMS-WH-05/2020/EPI_ISL_403928 | ||
| D (2579) → A | Wuhan/WIV07/2019/EPI_ISL_402130 | ||
| N (2708) → S | Wuhan/IPBCAMS-WH-01/2019/EPI_ISL_402123 | ||
| F (2908) → I | Wuhan/IPBCAMS-WH-01/2019/EPI_ISL_402123 | ||
| T (3058) → I | France/IDF0515/2020/EPI_ISL_408430 | ||
| S (3099) → L | Shenzhen/HKU-SZ-005/2020/EPI_ISL_405839 | ||
| L (3606) → F | Yunnan/IVDC-YN-003/2020/EPI_ISL_408480 Shandong/IVDC-SD-001/2020/EPI_ISL_408482 Chongqing/IVDC-CQ-001/2020/EPI_ISL_408481 Singapore/3/2020/EPI_ISL_407988 France/IDF0515/2020/EPI_ISL_408430 USA/AZ1/2020/EPI_ISL_406223 |
||
| E (3764) → D | Japan/KY-V-029/2020/EPI_ISL_408669 | ||
| N (3833) → K | Wuhan/WH01/2019/EPI_ISL_406798 | ||
| W (5308) → C | Taiwan/2/2020/EPI_ISL_406031 | ||
| T (5579) → I | USA/CA2/2020/EPI_ISL_406036 | ||
| I (6075) → T | England/02/2020/EPI_ISL_407073 England/01/2020/EPI_ISL_407071 |
||
| P (6083) → L | Japan/AI/I-004/2020/EPI_ISL_407084 | ||
| F (6309) → Y | Sichuan/IVDC-SC-001/2020/EPI_ISL_408484 | ||
| E (6565) → D | Shenzhen/SZTH-004/2020/EPI_ISL_406595 | ||
| K (6958) → R | Wuhan/WIV05/2019/EPI_ISL_402128 | ||
| D (7018) → N | Wuhan/WIV02/2019/EPI_ISL_402127 | ||
| Spike polyprotein | 14 | 8 | |
| F (32) → I | Wuhan/HBCDC-HB-01/2019/EPI_ISL_402132 | ||
| H (49) → Y | Guangdong/20SF174/2020/EPI_ISL_406531 Guangdong/20SF040/2020/EPI_ISL_403937 Guangdong/20SF028/2020/EPI_ISL_403936 |
||
| S (247) → R | Australia/VIC01/2020/EPI_ISL_406844 | ||
| N (354) → D | Shenzhen/SZTH-004/2020/EPI_ISL_406595 | ||
| D (364) → Y | Shenzhen/SZTH-004/2020/EPI_ISL_406595 | ||
| V (367) → F | France/IDF0372/2020/EPI_ISL_406596 France/IDF0373/2020/EPI_ISL_406597 |
||
| D (614) → G | Germany/BavPat1/2020/EPI_ISL_406862 | ||
| P (1143) → L | Australia/QLD02/2020/EPI_ISL_407896 | ||
| Intergenic region | 5 | N/A | |
| Envelope protein | 0 | 0 | |
| Matrix protein | 2 | 1 | |
| D (209) → H | Singapore/2/2020/EPI_ISL_407987 | ||
| Intergenic region | 6 | N/A | |
| Nucleocapsid protein | 7 | 4 | |
| T (148) → I | Shenzhen/SZTH-004/2020/EPI_ISL_406595 | ||
| S (194) → L | Shenzhen/SZTH-003/2020/EPI_ISL_406594 Foshan/20SF207/2020/EPI_ISL_406534 USA/CA3/2020/EPI_ISL_408008 USA/CA4/2020/EPI_ISL_408009 |
||
| S (202) → N | Australia/QLD02/2020/EPI_ISL_407896 | ||
| P (344) → S | Guangzhou/20SF206/2020/EPI_ISL_406533 | ||
| 3′UTR | 3 | N/A | |
| Complete genome | 93 | 42 |