Fig. 5.

Docking simulation to predict the binding of predicted overlapping G protein CD8 + and CD4 + T-cell epitopes to HLA-C*12:03 and HLA-DRB1*01:01 molecules, respectively. The colors, teal cyan and lime green indicate the surface structure of HLA-C*12:03 and HLA-DRB1*01:01, respectively. The red and hot pink colors indicate the CD8 + and CD4 + T-cell epitope, respectively. (A) CD8 + T-cell epitope “IAMTVLPAL” (affinity: − 8.5 kcal/mol) (B) CD4 + T-cell epitope “GIAMTVLPALAVFAL” (affinity: − 7.6 kcal/mol) (C) CD8 + T-cell epitope “FFDWFSGLM” (affinity: − 8.5 kcal/mol) (D) CD4 + T-cell epitope “GSWNFFDWFSGLMSW” (affinity: − 9.0 kcal/mol) (E) CD8 + T-cell epitope “FLLIYLGRT” (affinity: − 8.7 kcal/mol) and (F) CD4 + T-cell epitope “FFLLIYLGRTGLSKM” (affinity: − 6.5 kcal/mol). (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)